From what I read your statement is accurate. From speaking to people who are going through the new infusions Leqembi and Kisunla get rid of amyloid plaque doesn't mean the decline stops, and if the disease was driven by it then it would stop.
Also, studies show some slowing using these new drugs, but the disease still progresses. Therefore, the plaque is most likely a symptom. It could be the driver in some of the cases though, I think in genetic PSEN1 alzheimer's. I've read a paper discussing issue with the body not removing it and allowing to build up.
My wife’s family has PSEN1-mutation EAD (my wife didn’t inherit it). In that particular case it does seem that the mutated genes relate directly to Amyloid production and clearing, and there are ongoing clinical trials for the use of the new monoclonal antibody drugs in treating it. Two of my family members are in a trial for Remternetug, specifically. There is hope that in that specific case where 1. Amyloid buildup may actually be the cause and 2. you start treating it early, years before symptoms start, disease onset may be significantly delayed. There’s no way to know right now except to try it of course.
I read it somewhere that amyloid plaques were actually defensive mechanism of the body to counter the damage to brain from disease, so removing the plagues makes things worse for patients
My mother has early onset alzheimer's disease. We currently know very little about the disease and the current treatment options are controversial. The efficacy of the medications removing the amyloid plaque from the brain is questionable, as people still decline.
What makes alzheimer's difficult is that it is not really a single uniform disease. There are subtypes.
Since my mother has it, I was presented with an option of a genetic test. There are several genes which increase your risk. However, if one has PSEN1 that will 100% guarantee early onset alzheimer's at some point.
I'm still on the fence if I want to know.
I really hope we get some viable treatments for this terrible disease. Early onset azlheimer's is awful. I cannot imagine having malfunctioning brain.
How old is your mother? Iirc PSEN1 correlates to very early AD, like late 30s early 40s. My dad had full blown AD at 65, with serious cognitive decline starting at 63, and that felt very early to us all. My dad had no AD biomarkers on full genetic scan. My heart goes out to you and your family.
There are multiple specific possible mutations that cause 100% penetrant dominantly inherited early onset Alzheimer’s. And there are three genes where mutations can cause it: PSEN1, PSEN2, and APP. The average age of onset seems to depend on the specific mutation. In my (wife’s) family, onset is mid 40s to mid 50s. Some families get it even earlier, but 30s seems rare.
It’s sometimes frustrating to try to explain that the gene mutation in the family (PSEN1 in our case) means it’s a 100% chance you get it. Most people have never heard of it, so you get a lot of “well, maybe you’ll be lucky and it won’t affect you!” from well meaning people.
I’m very sorry for what you’re going through with your mom. My father in law had it and died a year ago at age 64 after 16 years of decline. Watching a truly brilliant person slowly lose their faculties and abilities until they don’t recognize their own family is awful.
Two of his kids have the mutation (not my wife, thankfully) and so we all hope that better treatments are available for them.
Give her -- and yourself -- lithium orotate. It's an asymmetric bet: it won't hurt, but very well might help. It has been found to be effective in murine models.
In order to deny a warranty claim the US, the manufacturer has to prove the issue has been caused by a modification or servicing.
Why would anyone want to service their call at a stealership? The prices are unfair and the quality of techs is awful. Better to find a small reliable shop.
Codex has been great for me for backend wiring, mapping and creating boiler plate code in C#. However, it seems when I go in to fix things its 60% front-end.
Idk, I like AI when it works, but it drives me insane when it keeps making errors. I've had a few errors which I figured out from documentation fairly quickly, provided said docs but the AI would still mess it up somehow.
> provided said docs but the AI would still mess it up somehow.
The AI is not intelligent. Its really hard to grasp cleanly. But it can't do anything logically like we do. Its pattern matching. It has to be a pattern its seen; then it can assemble them. If there are competing patterns - it'll trip up being consistent. Long established libraries and languages that change the least, it'll be best at. Anything newer it'll be bad at - even with documentation. The only way out is to give it tests, then it can loop over several simpler problems, where the errors (failed tests) match well onto the more basic primitives that don't really change (wrong string, wrong type, wrong structure, etc)
At $LARGE_ENTERPRISE_COMPANY, I've found that if you have:
1) A designer that uses Figma correctly (using well defined components / design systems)
2) A front-end framework as close to HTML / CSS as possible for the visuals (I have success with Web Components / Lit) with Figma MCP
The front-end is usually one-shot using frontier models. However in my experience, designers are all over the place with using Figma correctly.
Different people are driven by different things. Some people genuinely want to serve their nation and being a president is a huge honor to the family. You become part of history.
Others may be serving their own interests as it gives them access to all information.
This is Amazon Prime Music, an unasked for add-on to Amazon Prime to (in their minds) justify their raising the cost of Amazon Prime, so they managed to skip step 1. It was never a good value.
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