"The Last Lecture", by Randy Pausch. While it's by a well-known CS professor (who was dying of cancer at the time), it's not a technical talk, but about life and work, and how to make the most of it. One of the most inspiring things I've ever seen.
o u said steve jobs: really his announcement of the ipod was an incredible speech .. it ties together tech+art+music+apple and his vision appears pretty fresh.
And I upvoted you for explaining why you downvoted it. No point downvoting you. Comparing the end results of both, we only have a higher chance of a net benefit by upvoting you, regardless of whether I agree with you or not. I hope the rest of the HN community also takes this approach before voting.
https://www.youtube.com/watch?v=ji5_MqicxSo
Another fantastic one is Steve Jobs' 2005 commencement address at Stanford:
https://www.youtube.com/watch?v=UF8uR6Z6KLc