"They have been honed by many, many iterations."
For an environment and time that we no longer live in.
Evolution honed our instincts for a reason, but this reasoning was good for jungles and savannas, not urban sprawls and concrete jungles.
The danger being discussed above is that from other humans.
I don't think people have changed nearly enough to call our instincts about them into question.
You have now culture, law, education, and much more conditioning than 50000/100000/1000000 years ago. I would argue that much have changed regarding how other humans react to what we do.