And how do you propose we get all the users vaccinated with the fentanyl jab? Another round of mass vaccinations? Make all the kids in school do it? Forced vaccinations for anyone in jail or rehab? Honestly, all of those seem like bad ideas.
If the government subscribed wholly to utilitarian ethics, it's arguable that it would be an ethical imperative to contaminate the fentanyl supply with vaccine.
I don't agree, and think it's immoral and unethical to subject citizens to such medical treatment without informed consent. However, under some ethical systems, the improvement in aggregate health makes in an ethical necessity.
The US government has actually done similar things before, such as poisoning bootlegged alcohol with methanol. It's good that you bring it up because at some point somebody in power will.